LymphedemaV1, Main, Exploration, bibRecord, 004355

Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

Identifieur interne : 004355 ( Main/Exploration ); précédent : 004354; suivant : 004356

Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

Auteurs : Vivekanandhan Aravindhan ; Viswanathan Mohan ; Jayagopi Surendar ; Maradana Muralidhara Rao ; Rajamanickam Anuradha ; Mohan Deepa ; Subash Babu

Source :

The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2012.

RBID : PMC:3335688

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Facteur de nécrose tumorale alpha (sang), Facteurs de risque, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (physiopathologie), Filariose lymphatique (sang), Humains, Inde (épidémiologie), Inflammation (parasitologie), Inflammation (sang), Inflammation (épidémiologie), Interleukine-6 (sang), Maladie des artères coronaires (parasitologie), Maladie des artères coronaires (sang), Maladie des artères coronaires (épidémiologie), Marqueurs biologiques (sang), Mâle, Population rurale, Protéine C-réactive (métabolisme), Prévalence, Sujet âgé, Études épidémiologiques.
MESH :
- diagnostic : Filariose lymphatique.
- métabolisme : Protéine C-réactive.
- parasitologie : Inflammation, Maladie des artères coronaires.
- physiopathologie : Filariose lymphatique.
- sang : Facteur de nécrose tumorale alpha, Filariose lymphatique, Inflammation, Interleukine-6, Maladie des artères coronaires, Marqueurs biologiques.
- épidémiologie : Inde, Inflammation, Maladie des artères coronaires.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Population rurale, Prévalence, Sujet âgé, Études épidémiologiques.
Wicri :
- geographic : Inde.

English descriptors

KwdEn :
- Adult, Aged, Biomarkers (blood), C-Reactive Protein (metabolism), Coronary Artery Disease (blood), Coronary Artery Disease (epidemiology), Coronary Artery Disease (parasitology), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (physiopathology), Epidemiologic Studies, Female, Humans, India (epidemiology), Inflammation (blood), Inflammation (epidemiology), Inflammation (parasitology), Interleukin-6 (blood), Male, Middle Aged, Prevalence, Risk Factors, Rural Population, Tumor Necrosis Factor-alpha (blood).
MESH :
- chemical , blood : Biomarkers, Interleukin-6, Tumor Necrosis Factor-alpha.
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : India.
- blood : Coronary Artery Disease, Elephantiasis, Filarial, Inflammation.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Coronary Artery Disease, Inflammation.
- parasitology : Coronary Artery Disease, Inflammation.
- physiopathology : Elephantiasis, Filarial.
- Adult, Aged, Epidemiologic Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Rural Population.

Abstract

Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD⁻ and CAD⁺ subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF⁺ and LF⁻ subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD⁺ subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335688

DOI: 10.4269/ajtmh.2012.11-0773
PubMed: 22556082
PubMed Central: 3335688

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
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<term>C-Reactive Protein (metabolism)</term>
<term>Coronary Artery Disease (blood)</term>
<term>Coronary Artery Disease (epidemiology)</term>
<term>Coronary Artery Disease (parasitology)</term>
<term>Elephantiasis, Filarial (blood)</term>
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<term>Inflammation (blood)</term>
<term>Inflammation (epidemiology)</term>
<term>Inflammation (parasitology)</term>
<term>Interleukin-6 (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>Rural Population</term>
<term>Tumor Necrosis Factor-alpha (blood)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteur de nécrose tumorale alpha (sang)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Filariose lymphatique (diagnostic)</term>
<term>Filariose lymphatique (physiopathologie)</term>
<term>Filariose lymphatique (sang)</term>
<term>Humains</term>
<term>Inde (épidémiologie)</term>
<term>Inflammation (parasitologie)</term>
<term>Inflammation (sang)</term>
<term>Inflammation (épidémiologie)</term>
<term>Interleukine-6 (sang)</term>
<term>Maladie des artères coronaires (parasitologie)</term>
<term>Maladie des artères coronaires (sang)</term>
<term>Maladie des artères coronaires (épidémiologie)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mâle</term>
<term>Population rurale</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Prévalence</term>
<term>Sujet âgé</term>
<term>Études épidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Interleukin-6</term>
<term>Tumor Necrosis Factor-alpha</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term>
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</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronary Artery Disease</term>
<term>Elephantiasis, Filarial</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronary Artery Disease</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Inflammation</term>
<term>Maladie des artères coronaires</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Coronary Artery Disease</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
<term>Filariose lymphatique</term>
<term>Inflammation</term>
<term>Interleukine-6</term>
<term>Maladie des artères coronaires</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Inde</term>
<term>Inflammation</term>
<term>Maladie des artères coronaires</term>
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<term>Aged</term>
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<term>Adulte d'âge moyen</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en"><p>Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (<italic>N</italic>
 = 236) and with (<italic>N</italic>
 = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD<sup>−</sup>
 and CAD<sup>+</sup>
 subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF<sup>+</sup>
 and LF<sup>−</sup>
 subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD<sup>+</sup>
 subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name>
<name sortKey="Aravindhan, Vivekanandhan" sort="Aravindhan, Vivekanandhan" uniqKey="Aravindhan V" first="Vivekanandhan" last="Aravindhan">Vivekanandhan Aravindhan</name>
<name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<name sortKey="Deepa, Mohan" sort="Deepa, Mohan" uniqKey="Deepa M" first="Mohan" last="Deepa">Mohan Deepa</name>
<name sortKey="Mohan, Viswanathan" sort="Mohan, Viswanathan" uniqKey="Mohan V" first="Viswanathan" last="Mohan">Viswanathan Mohan</name>
<name sortKey="Rao, Maradana Muralidhara" sort="Rao, Maradana Muralidhara" uniqKey="Rao M" first="Maradana Muralidhara" last="Rao">Maradana Muralidhara Rao</name>
<name sortKey="Surendar, Jayagopi" sort="Surendar, Jayagopi" uniqKey="Surendar J" first="Jayagopi" last="Surendar">Jayagopi Surendar</name>
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Serveur d'exploration sur le lymphœdème

Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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